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館長・顧問論文

原著論文

Riyuji Yamashita, Shohei Fujii, Ryo Ushioda, & Kazuhiro Nagata

Ca2+ imbalance caused by ERdj5 deletion affects mitochondrial fragmentation

Scientific Reports Volume 11, Article number: 20772 (2021)

Yuxia Zhanga, Michio Inoue, Akihisa Tsutsumi, Satoshi Watanabe, Tomohiro Nishizawac, Kazuhiro Nagata, Masahide Kikkawa and Kenji Inaba

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Science Advance 6(33) eabb0147 (2020)
doi.org/10.1101/2020.03.28.012849.

A. Kohler, M. Morgelin, J.M. Gebauer, S. Ocal, T. Imhof, M. Koch, K. Nagata, M. Paulsson, M. Aumailley, U. Baumann, F. Zacke & G. Sengle:

New specific Hsp47 functions in collagen subfamily chaperoning.

FASEB J. 34:12040-12052 (2020)

Yo-hei Yamamoto, Ayano Kasai, Hiroko Omori, Tomoe Takino, Munechika Sugihara, Tetsuo Umemoto, Maho Hamasaki, Tomohisa Hatta, Tohru Natsume, Richard I. Morimoto, Ritsuko Arai, Satoshi Waguri, Miyuki Sato, Ken Sato, Shoshana Bar-Nun,Tamotsu Yoshimori, Takeshi Noda and Kazuhiro Nagata

ERdj8 governs the size of autophagosomes during the formation process

J. Cell. Biol. 219(8): e201903127 (2020)

M. Yoshida, M. Saito, S. Ito, K. Ogawa, N. Goshima, K. Nagata & T. Doi

Structure-Activity Relationship Study on Col-003, a Protein-Protein Interaction Inhibitor between Collagen and Hsp47.

Chem Pharm Bull. 68(3):220-226 (2020)

G. Xiong, J. Chen, G. Zhang, S. Wang, K. Kawasaki, J. Zhu, Y. Zhang, K. Nagata, Z. Li, BP. Zhou, R. Xu

Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.

Proc Natl Acad Sci U S A. 117 (7) :3748-3758 (2020)
doi.org/10.1073/pnas.1911951117

S. Ito, M. Saito, M. Yoshida, K. Takeuchi, T. Doi & K. Nagata

A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction.

J Biol Chem. 294(44):15962-15972 (2019)
doi: 10.1074/jbc.RA119.010567

KK. Fujii, Y. Taga, T. Sakai, S. Ito, S. Hattori, K. Nagata & T. Koide

Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout.

Sci Rep.9(1):17433. (2019)
DOI:10.1038/s41598-019-53962-0

H. Khalil, O. Kanisicak, RJ. Vagnozzi, AK. Johansen, BD. Maliken, V. Prasad, JG. Boyer, MJ. Brody, T. Schips, KK. Kilian, RN. Correll, K. Kawasaki, K. Nagata & JD. Molkentin

Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart.

JCI Insight 4(15):e128722 (2019)

M. Inoue, N. Sakuta, S. Watanabe, Y. Zhang, K. Yoshikaie, R. Ushioda, Y. Kato, J. Takeda, T. Tsukazaki, K. Nagata & K. Inaba

Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay

Cell Rep.27(4)1221-1230 (2019)
10.1016/j.celrep.2019.03.106

S. Ito & K. Nagata

Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease.

J Biol Chem. 294(6):2133-2141 (2019)
DOI: 10.1074/jbc.TM118.002812

M. Sugihara, D. Morito, S. Ainuki, Y. Hirano, K. Ogino, A. Kitamura, H. Hirata & K. Nagata

The AAA+ ATPase/ubiquitin ligase mysterin cytoplasmic lipid droplets

J. Cell. Biol. 218(3):949-960 (2019)
DOI: 10.1083/jcb.201712120 | Published January 31, 2019

R. Ushioda & K. Nagata

Redox-Mediated Reguiatory Mechanisms of Endplasmic Reticulum Homeostasis.

Cold Spring Harbor Perspectives in Biology”Protein Homeostasis SECOND EDITION”
Cold Spring Harbor Laboratory press 1;11(5), (2019)
doi: 10.1101/cshperspect.a033910

H.H. Kampinga, C. Andreasson, A. Barducci, M.E.Cheetham, D. Cyr, C. Emanuelsson, P. Genevaux, J.E. Gestwicki, P. Goloubinoff, J. Huerta-Cepas, J. Kirstein, K. Liberek, M.P. Mayer, K. Nagata, N.B. Nillegoda, P. Pulido, C. Ramos, P. De Los Rios, S. Rospert, R. Rosenzweig, C. Sahi, M. Taipale, B. Tomiczek, R. Ushioda, J.C. Young,R. Zimmermann, A. Zylicz, M. Zylicz, E.A. Craig & J. Marszalek

Function, evolution, and structure of J-domain proteins.

Cell Stress and Chaperones 24(1):7-15 (2019)
doi: 10.1007/s12192-018-0948-4. Epub 2018 Nov 26.