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館長・顧問論文

原著論文

Riyuji Yamashita, Shohei Fujii, Ryo Ushioda, & Kazuhiro Nagata

Ca2+ imbalance caused by ERdj5 deletion affects mitochondrial fragmentation

Scientific Reports Volume 11, Article number: 20772 (2021)

Zhang K, Bao R, Huang F, Yang K, Ding Y, Lauterboeck L, Yoshida M, Long Q, Yang Q.

ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis.

Lab Invest. 2021 Oct 4. doi: 10.1038/s41374-021-00670-x. Online ahead of print.PMID: 34608240

Taira Y, Ikuta Y, Inamori S, Nunome M, Nakano M, Suzuki T, Matsuda Y, Tsudzuki M, Teramoto M, Iida H, Kondoh H.

The formation of multiple pituitary pouches from the oral ectoderm causes ectopic lens development in hedgehog signaling-defective avian embryos.

Dev Dyn. 2020 249(12):1425-1439. doi: 10.1002/dvdy.222.

Yuxia Zhanga, Michio Inoue, Akihisa Tsutsumi, Satoshi Watanabe, Tomohiro Nishizawac, Kazuhiro Nagata, Masahide Kikkawa and Kenji Inaba

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Science Advance 6(33) eabb0147 (2020)
doi.org/10.1101/2020.03.28.012849.

Iwanami N, Takeshita K, Lawir DF, Suetake I, Tajima S, Sikora K, Trancoso I, ÓMeara C, Siamishi I, Takahama Y, Furutani-Seiki M, Kondoh H, Yonezawa Y, Schorpp M, Boehm T.

Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.

iScience. 2020 24;23(7):101260. doi: 10.1016/j.isci.2020.101260.

A. Kohler, M. Morgelin, J.M. Gebauer, S. Ocal, T. Imhof, M. Koch, K. Nagata, M. Paulsson, M. Aumailley, U. Baumann, F. Zacke & G. Sengle:

New specific Hsp47 functions in collagen subfamily chaperoning.

FASEB J. 34:12040-12052 (2020)

Yo-hei Yamamoto, Ayano Kasai, Hiroko Omori, Tomoe Takino, Munechika Sugihara, Tetsuo Umemoto, Maho Hamasaki, Tomohisa Hatta, Tohru Natsume, Richard I. Morimoto, Ritsuko Arai, Satoshi Waguri, Miyuki Sato, Ken Sato, Shoshana Bar-Nun,Tamotsu Yoshimori, Takeshi Noda and Kazuhiro Nagata

ERdj8 governs the size of autophagosomes during the formation process

J. Cell. Biol. 219(8): e201903127 (2020)

Inamori S, Fujii M, Satake S, Iida H, Teramoto M, Sumi T, Meno C, Ishii Y, Kondoh H.

Modeling early stages of endoderm development in epiblast stem cell aggregates with supply of extracellular matrices.

Dev Growth Differ. 2020 62(4):243-259. doi: 10.1111/dgd.12663.

Iida H, Furukawa Y, Teramoto M, Suzuki H, Takemoto T, Uchikawa M, Kondoh H.

Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2.

Genes Cells. 2020 25(4):242-256. doi: 10.1111/gtc.12753.

M. Yoshida, M. Saito, S. Ito, K. Ogawa, N. Goshima, K. Nagata & T. Doi

Structure-Activity Relationship Study on Col-003, a Protein-Protein Interaction Inhibitor between Collagen and Hsp47.

Chem Pharm Bull. 68(3):220-226 (2020)

Teramoto M, Sugawara R, Minegishi K, Uchikawa M, Takemoto T, Kuroiwa A, Ishii Y, Kondoh H.

The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components.

Biol Open. 2020 9(2):bio048728. doi: 10.1242/bio.048728.

G. Xiong, J. Chen, G. Zhang, S. Wang, K. Kawasaki, J. Zhu, Y. Zhang, K. Nagata, Z. Li, BP. Zhou, R. Xu

Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.

Proc Natl Acad Sci U S A. 117 (7) :3748-3758 (2020)
doi.org/10.1073/pnas.1911951117

S. Ito, M. Saito, M. Yoshida, K. Takeuchi, T. Doi & K. Nagata

A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction.

J Biol Chem. 294(44):15962-15972 (2019)
doi: 10.1074/jbc.RA119.010567

KK. Fujii, Y. Taga, T. Sakai, S. Ito, S. Hattori, K. Nagata & T. Koide

Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout.

Sci Rep.9(1):17433. (2019)
DOI:10.1038/s41598-019-53962-0

H. Khalil, O. Kanisicak, RJ. Vagnozzi, AK. Johansen, BD. Maliken, V. Prasad, JG. Boyer, MJ. Brody, T. Schips, KK. Kilian, RN. Correll, K. Kawasaki, K. Nagata & JD. Molkentin

Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart.

JCI Insight 4(15):e128722 (2019)

M. Inoue, N. Sakuta, S. Watanabe, Y. Zhang, K. Yoshikaie, R. Ushioda, Y. Kato, J. Takeda, T. Tsukazaki, K. Nagata & K. Inaba

Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay

Cell Rep.27(4)1221-1230 (2019)
10.1016/j.celrep.2019.03.106

S. Ito & K. Nagata

Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease.

J Biol Chem. 294(6):2133-2141 (2019)
DOI: 10.1074/jbc.TM118.002812

M. Sugihara, D. Morito, S. Ainuki, Y. Hirano, K. Ogino, A. Kitamura, H. Hirata & K. Nagata

The AAA+ ATPase/ubiquitin ligase mysterin cytoplasmic lipid droplets

J. Cell. Biol. 218(3):949-960 (2019)
DOI: 10.1083/jcb.201712120 | Published January 31, 2019